syntheses, antifungal and antibacterial activities of substituted 1,2, ctrimoles

the reaction of readily available 1 -methyl-4-nitropyrrole-2- carboxylic acid (1) with thionyl chloride afforded the corresponding acyl chloride 2. the reaction of compound 2 with thiosemicarbazides yielded 1-(1 -methyl-4-nitrop yrrole-2-carbony1)- thiosemicarbazides (3) which cyclized in basic medium to 5-(1-methyl-4-nitropyrrole- 2-y1)-2,4-dihydro-3h- l,2,4-triazole-3- thione 4. alkylation and subsequent oxidation of 4 gave 6. the antibacterial and antifungal activities of 6a to 6f against a number of microorganisms were determined. only compounds 6b and 6c had moderate activity against aspergilus niger